A crystal molecular conformation of leucine‐enkephalin related to the morphine molecule
1989; Wiley; Volume: 28; Issue: 1 Linguagem: Inglês
10.1002/bip.360280106
ISSN1097-0282
AutoresA. Aubry, Nicolas Birlirakis, Maria Sakarellos‐Daitsiotis, C. Sakarellos, Michel Marraud,
Tópico(s)Pharmacological Receptor Mechanisms and Effects
ResumoAbstract Leucine‐enkephalin (Try 1 ‐Gly 2 ‐Gly 3 ‐Phe 4 ‐Leu 5 ) has been crytallized as a trihydrate from water solution. X‐ray diffraction reveals a tightly folded molecular conformation with two fused βIII‐ (Gly 2 ‐Gly 3 ) and βI‐ (Gly 3 ‐Phe 4 ) turns. The Tyr 1 and Phe 4 aromatic rings have a close orthogonal arrangement analogous to the tyramine and cyclohexenyl rings in morphine. This suggests that the conformation found in the trihydrate crystal structure could be required for recognition by μ‐receptor sites.
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