Portal de Periódicos da CAPES

SAFETY OF SYSTEMIC OXYTETRACYCLINE (TERRAMYCIN) THERAPY FOLLOWING OR WITH TOPICAL THERAPY

1954; American Medical Association; Volume: 69; Issue: 5 Linguagem: Inglês

10.1001/archderm.1954.01540170091018

1538-3652

Donald N. Tschan,

Dermatology and Skin Diseases

Sulfonamides and penicillin were extolled as excellent therapeutic agents for the local therapy of skin infections immediately after their introduction. It was quickly learned that topical application, particularly of the sulfonamides, at times resulted in sensitization which prevented their later use as an oral medication. As stated by Sulzberger and Baer, "The sulfonamides have a sensitizing potential equal to or greater than that of many older and some newer antibacterial agents which can be used in topical therapy, e. g., mercurials, phenolic substances, sulfur, tyrothricin, chlorhydroxyquinolines, etc." In the same article they point out that penicillin has a great or greater sensitizing potential and produces more by-effects than many older and newer remedies which possess analogous therapeutic properties on external application. It has been pointed out by Prystowsky that the problem of contact sensitization has existed ever since the advent of topical therapy, but prior to the widespread