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Genetic code deviations in the ciliates: evidence for multiple and independent events.

1995; Springer Nature; Volume: 14; Issue: 13 Linguagem: Inglês

10.1002/j.1460-2075.1995.tb07329.x

1460-2075

Anne Baroin Tourancheau, Nora Tsao, Lawrence A. Klobutcher, Ronald E. Pearlman, A Adoutte,

Microbial Community Ecology and Physiology

Research Article3 July 1995free access Genetic code deviations in the ciliates: evidence for multiple and independent events. A.B. Tourancheau A.B. Tourancheau Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author N. Tsao N. Tsao Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author L.A. Klobutcher L.A. Klobutcher Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author R.E. Pearlman R.E. Pearlman Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author A. Adoutte A. Adoutte Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author A.B. Tourancheau A.B. Tourancheau Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author N. Tsao N. Tsao Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author L.A. Klobutcher L.A. Klobutcher Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author R.E. Pearlman R.E. Pearlman Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author A. Adoutte A. Adoutte Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. Search for more papers by this author Author Information A.B. Tourancheau1, N. Tsao1, L.A. Klobutcher1, R.E. Pearlman1 and A. Adoutte1 1Laboratoire de Biologie Cellulaire 4 (URA 1134), Université Paris-Sud, Orsay, France. The EMBO Journal (1995)14:3262-3267https://doi.org/10.1002/j.1460-2075.1995.tb07329.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info In several species of ciliates, the universal stop codons UAA and UAG are translated into glutamine, while in the euplotids, the glutamine codon usage is normal, but UGA appears to be translated as cysteine. Because the emerging position of this monophyletic group in the eukaryotic lineage is relatively late, this deviant genetic code represents a derived state of the universal code. The question is therefore raised as to how these changes arose within the evolutionary pathways of the phylum. Here, we have investigated the presence of stop codons in alpha tubulin and/or phosphoglycerate kinase gene coding sequences from diverse species of ciliates scattered over the phylogenetic tree constructed from 28S rRNA sequences. In our data set, when deviations occur they correspond to in frame UAA and UAG coding for glutamine. By combining these new data with those previously reported, we show that (i) utilization of UAA and UAG codons occurs to different extents between, but also within, the different classes of ciliates and (ii) the resulting phylogenetic pattern of deviations from the universal code cannot be accounted for by a scenario involving a single transition to the unusual code. Thus, contrary to expectations, deviations from the universal genetic code have arisen independently several times within the phylum. Previous ArticleNext Article Volume 14Issue 131 July 1995In this issue RelatedDetailsLoading ...