Portal de Periódicos da CAPES

A lipid cofactor for the acid lipase of the castor bean

1962; Elsevier BV; Volume: 7; Issue: 5 Linguagem: Inglês

10.1016/0006-291x(62)90318-2

1090-2104

Robert L. Ory, Aaron M. Altschul,

Pancreatic function and diabetes

Lipases are currently classified among hydrolases. They participate in transfer reactions in which molecules other than water can act as the acceptor for fatty acyl radicals. No bonds other than carboxyl ester bonds have ever been found to be hydrolyzed by lipases. The mammalian lipases are classified into three groups—the lipases discharged into the digestive tract by specialized organs, tissue lipases, and milk lipases. Among the digestive lipases, the enzyme synthesized by the acinar cells of the pancreas plays an essential role during the intraluminar digestion of dietary triglycerides because of its unusually high molecular activity. Mammalian liapses are also present in a number of tissues or organs of mammals such as heart, brain, muscle, arteries, kidney, adipose tissue, and serum. Lipases are widely distributed among bacteria, yeasts, and fungi. Most of them are discharged through the external membrane into the culture medium (exocellular lipases). The existence of a lipase in pancreatic juice can be easily demonstrated by activity determinations, either directly or after fractionation of the enzymes by ion exchange chromatography. Like the other pancreatic enzymes, lipase is stored in zymogen granules before extrusion into the secretory ducts.