Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury
2008; Taylor & Francis; Volume: 22; Issue: 2 Linguagem: Inglês
10.1080/02699050801888816
ISSN1362-301X
AutoresLaura Miles, Robert I. Grossman, Glyn Johnson, James S. Babb, Leonard Diller, Matilde Inglese,
Tópico(s)Traumatic Brain Injury and Neurovascular Disturbances
ResumoTo explore whether baseline diffusion tensor imaging (DTI) metrics are predictive of cognitive functioning 6 months post-injury in patients with mild traumatic brain injury (MTBI).Seventeen patients with MTBI and 29 sex- and age-matched healthy controls were studied.Participants underwent an MRI protocol including DTI, at an average of 4.0 (range: 1-10) days post-injury. Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the following white matter (WM) regions: centra semiovale, the genu and the splenium of the corpus callosum and the posterior limb of the internal capsule. Participants underwent neuropsychological (NP) testing at baseline and at 6-month follow-up. Least squares regression analysis was used to evaluate the association of MD and FA with each NP test score at baseline and follow-up.Compared to controls, average MD was significantly higher (p = 0.02) and average FA significantly lower (p = 0.0001) in MTBI patients. At the follow-up, there was a trend toward a significant association between baseline MD and response speed (r = -0.53, p = 0.087) and a positive correlation between baseline FA and Prioritization form B (r = 0.72, p = 0.003).DTI may provide short-term non-invasive predictive markers of cognitive functioning in patients with MTBI.
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