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Induction of Quinone Reductase by Withanolides

2002; American Chemical Society; Volume: 65; Issue: 5 Linguagem: Inglês

10.1021/np0106337

1520-6025

Rosana I. Misico, Lynda L. Song, Adriana S. Veleiro, Adriana M. Cirigliano, M. Cristina Tettamanzi, Gerardo Burton, Gloria M. Bonetto, Viviana E. Nicotra, Gloria L. Silva, Roberto R. Gil, Juan C. Oberti, A. Douglas Kinghorn, John M. Pezzuto,

Ethnobotanical and Medicinal Plants Studies

Thirty-seven naturally occurring withanolides (1−37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2−5, 7−9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland.