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(14C) streptozotocin: Its distribution and interaction with nucleic acids and proteins

1981; Elsevier BV; Volume: 30; Issue: 14 Linguagem: Inglês

10.1016/0006-2952(81)90198-2

1873-2968

Pellegrino Masiello, EH Karunanayake, E. Bergamini, D HEARSE, G. Mellows,

Peroxisome Proliferator-Activated Receptors

The tissue distribution and interaction with cellular nucleic acids and proteins of (2′-14C) streptozotocin and (3′-methyl-14C) streptozotocin has been investigated in the rat during the first hour following their intravenous injection. The investigations have been carried out with animals of two different age groups. With each labelled form of the drug, the injected radioactivity was cleared from the blood, most of it appearing in high activity in kidney and liver. Following the administration of (3′-methyl-14C) streptozotocin, in all animals relatively large amounts of injected radioactivity were associated with the nucleic acid and protein fractions of pancreas, liver and kidney. In contrast, only very small amounts of injected radioactivity were associated with these organs following the administration of (2′-14C) streptozotocin. The highest level of association of the methyl label was observed with pancreatic proteins. Between the two age groups, different radioactivity profiles for renal tissue were observed and some differences were detected in the association of the methyl label with the cellular macromolecules. These results are discussed in relation to the diabetogenic and tumourigenic properties of the drug.