Pt(II)- or Au(III)-Catalyzed [3+2] Cycloaddition of Metal-Containing Azomethine Ylides: Highly Efficient Synthesis of the Mitosene Skeleton
2005; American Chemical Society; Volume: 8; Issue: 2 Linguagem: Inglês
10.1021/ol052610f
ISSN1523-7060
AutoresHiroyuki Kusama, Yuichi Miyashita, Jun Takaya, Nobuharu Iwasawa,
Tópico(s)Synthesis and Catalytic Reactions
Resumo[reaction: see text] Only 1-3 mol % of PtCl(2) or AuBr(3) was sufficient to promote generation and [3+2] cycloaddition of transition-metal-containing azomethine ylides derived from N-(o-alkynylphenyl)imines bearing an internal alkyne moiety. A highly efficient method for the preparation of synthetically useful tricyclic indole derivatives having a substituent at the 3-position of the indole nucleus was established by this method.
Referência(s)