Portal de Periódicos da CAPES

L-Asparaginase (Leunase) Induced Pancreatitis in Childhood Acute Lymphoblastic Leukemia

1998; Taylor & Francis; Volume: 15; Issue: 6 Linguagem: Inglês

10.3109/08880019809018315

1521-0669

S. Sahu, Shizuya Saika, Swati Pai, S H Advani,

Neonatal Health and Biochemistry

A major complication of L-asparaginase therapy in acute lymphoblastic leukemia (ALL) is pancreatitis. Among the 915 cases of ALL seen over last 10 years, 19 (2%) developed pancreatitis. Median age was 5.5 years with a median duration of symptoms of 4 weeks. All cases had raised serum amylase and lipase. Pancreatitis was not related to the dose/duration of L-asparaginase therapy. Ultrasonography can be used as a corroborative investigation for diagnosis along with serum chemistries. Close clinical monitoring of children for early diagnosis of this complication is recommended.