Artigo Revisado por pares

The Thymus, Thymosin and Anti‐Thymosin 1, 2

1970; Wiley; Volume: 19; Issue: 2 Linguagem: Inglês

10.1111/j.1423-0410.1970.tb01501.x

ISSN

1423-0410

Autores

Gérald Goldstein,

Tópico(s)

Myasthenia Gravis and Thymoma

Resumo

Vox SanguinisVolume 19, Issue 2 p. 97-104 The Thymus, Thymosin and Anti-Thymosin12 G. Goldstein, Corresponding Author G. Goldstein New York University Medical Centre, New York, N.Y. Career Scientist of The Health Research Council of The City of New York.New York University Medical Center, 400 East 34th Street, New York, NY 10016 (USA)Search for more papers by this author G. Goldstein, Corresponding Author G. Goldstein New York University Medical Centre, New York, N.Y. Career Scientist of The Health Research Council of The City of New York.New York University Medical Center, 400 East 34th Street, New York, NY 10016 (USA)Search for more papers by this author First published: August 1970 https://doi.org/10.1111/j.1423-0410.1970.tb01501.xCitations: 4 1 Invited paper. 2 Supported by U.S. Public Service Grant NS-09173-01. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Beard, J. The source of leucocytes and the true function of the thymus. Anat. Anz. 18: 550 (1900). 2 Bomskov, C. H. and Sladovic, L. Der Thymus als innersekretorisches Organ. Deut. Med. Wschr. 22: 589 (1940). 3 De Somer, P.; Denys, P. Jr. and Leyton, R. Activity of a non cellular calf thymus extract in normal and thymectomized mice. Life Sci. 11: 810 (1963). 4 Ford, C. E. Traffic of lymphoid cells in the body, in Wolstenholme and Porter: Thymus: Experimental and clinical studies, p. 131, Ciba Found. (Chur- Symp. chill, London 1966). 5 Goldstein, A. L.; Asanuma, Y. and White, A. The thymus as an endocrine gland: Properties of thymosin, a new thymus hormone. Recent Progr. Hormone Res. 26: in press (1970). 6 Goldstein, A. L.; Asanuma, Y.; Battisto, J. R.; Hardy, M. A.; Quint, J. and White, A. Influence of thymosin on cell-mediated and humoral immune responses in normal and in immunologically deficient mice. J. Immunol. 104: 359 (1970). 7 Goldstein, A. L.; Banerjee, S. and White, A. Preparation and properties of thymostatin, a new thymic inhibitor of DNA and RNA synthesis. Proc. nat. Acad. Sci., Wash. 57: 821 (1967). 8 Goldstein, A. L.; Slater, F. D. and White, A. Preparation, assay and partial purification of thymic lymphocytopoietic factor (thymosin). Proc. nat. Acad. Sci., Wash. 56: 1010 (1966). 9 Goldstein, G. The thymus and neuromuscular function. A substance in thymus which causes myositis and myasthenic neuromuscular block in guinea pigs. Lancet ii: 119 (1968). 10 Goldstein, G. and Hofmann, W. W. Endocrine function of the thymus affecting neuromuscular transmission. Clin. exp. Immunol. 4: 181 (1969). 11 Goldstein, G. and Mackay, I. R. The human thymus, p. 182 (Heinemann, London 1969). 12 Gowans, J. L. The recirculation of lymphocytes from blood to lymph in the rat. J. Physiol., Lond. 146: 54 (1959). 13 Gowans, J. L.; Gesner, B. M. and McGregor, D. D. The immunological activity of lymphocytes; in Wolstenholme and O'Connor, Biological activity of the leucocyte, p. 32, Ciba Found. Study Group No. 10 (Churchill, London 1961). 14 Hammar, J. A. The new views as to the morphology of the thymus gland and their bearing on the problem of the function of the thymus. Endocrinology 5: 543 (1921). 15 Hardy, M. A.; Quint, J.; Goldstein, A. L.; State, D. and White, A. Effect of thymosin and an anti-thymosin serum on allograft survival in mice. Proc. nat. Acad. Sci., Wash. 61: 875 (1968). 16 Hardy, M. A.; Quint, J.; Goldstein, A. L.; White, A.; State, D. and Battisto, J. R. Effects of an antiserum to calf thymosin on lymphoid cells in vitro. Proc. Soc. exp. Biol., N.Y. 130: 214 (1969). 17 Kindred, J. E. Quantitative studies on lymphoid tissues. Ann. N.Y. Acad. Sci. 59: 746 (1955). 18 Klein, J. J.; Goldstein, A. L. and White, A. Enhancement of in vivo incorporation of labelled precursors into DNA and total protein of mouse lymph nodes after administration of thymic extracts. Proc. nat. Acad. Sci., Wash. 53: 812 (1965). 19 Law, L. W. and Agnew, H. D. Effect of thymic extracts on restoration of immunologic competence in thymectomized mice. Proc. Soc. exp. Biol., N.Y. 127: 953 (1968). 20 Law, L. L.; Goldstein, A. L. and White, A. Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice. Nature, Lond. 219: 1391 (1968). 21 Levey, R. H.; Trainin, N. and Law, L. W. Evidence for function of thymic tissue in diffusion chambers implanted in neonatally thymectomized mice. Preliminary report. J. nat. Cancer Inst. 31: 199 (1963). 22 Martinez, C.; Kersey, J.; Papermaster, B. W. and Good, R. A. Skin homograft survival in thymectomized mice. Proc. Soc. exp. Biol., N.Y. 109: 193 (1962). 23 Metcalf, D. The thymic origin of the plasma lymphocytosis stimulating factor. Brit. J. Cancer 10: 442 (1956). 24 Metcalf, D. and Wiadrowski, M. Adoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue. Cancer Res. 26: 483 (1966). 25 Miller, J. F. A. P. Immunological function of the thymus. Lancet ii: 748 (1961). 26 Miller, J. F. A. P. Role of the thymus in transplantation immunity. Ann. N.Y. Acad. Sci. 99: 340 (1962). 27 Miller, J. F. A. P.; De Burgh, P. M.; Dukor, P.; Grant, G.; Allman, V. and House, W. Regeneration of thymus grafts. II. Effects on immunological capacity. Clin. exp. Immunol. 1: 61 (1966). 28 Nakamoto, A. Influence of the thymus on the blood, especially on lymphocytes. II. Influence of thymus extract on peripheral blood lymphocytes. Acta hemat. Jap. 20: 187 (1957). 29 Osoba, P. and Miller, J. F. A. P. Evidence for a humoral thymus factor responsible for the maturation of immunological faculty. Nature, Lond. 199: 653 (1963). 30 Rehn, E. Die Hyperfunktion des Thymus als Krankheit. Dtsch. med. Wschr. 66: 594 (1940). 31 Roberts, S. and White, A. Biochemical characterization of lymphoid tissue proteins. J. Biol. Chem. 178: 151 (1949). 32 Small, M. and Thainin, N. Increase in antibody forming cells of neonatally thymectomized mice receiving calf thymus extract. Nature, Lond. 216: 377 (1967). 33 Trainin, N.; Bejerano, A.; Stahilevitch, M.; Goldring, D. and Small, M. A thymic factor preventing wasting and influencing lymphopoiesis in mice. Israel J. Med. 2: 549 (1966). 34 Trainin, N.; Burger, M. and Kaye, A. M. Some characteristics of a thymic humoral factor determined by assay in vivo of DNA synthesis in lymphnodes of thymectomized mice. Biochem. Pharmacol. 16: 711 (1967). 35 Trainin, N. and Linker-Israeli, M. Restoration of immunological reactivity of thymectomized mice by calf thymus extracts. Cancer Res. 27: 309 (1967). 36 Trainin, N.; Small, M. and Globerson, A. Immunocompetence of spleen cells from neonatally thymectomized mice conferred in vitro by a syngeneic thymus extract. J. exp. Med. 130: 765 (1969). 37 Weissman, I. Thymus cell migration. J. exp. Med. 126: 291 (1967). 38 Weller, G. L., jr. Development of the thyroid, parathyroid and thymus glands in man. Contrib. Embryol. Carnegie Inst. (No. 141) 24: 93 (1933). Citing Literature Volume19, Issue2August 1970Pages 97-104 ReferencesRelatedInformation

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