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Glyco‐tuftsin derivatives modulate interleukin‐1 and tumor necrosis factor production

1991; Wiley; Volume: 37; Issue: 3 Linguagem: Inglês

10.1111/j.1399-3011.1991.tb00265.x

0367-8377

Raniero Rocchi, Laura Biondi, Fernando Filira, Esther Tzehoval, Shlomo Dagan, Mati Fridkin,

Neuropeptides and Animal Physiology

Six Thr 1 (O‐glyco)‐derivatives of the “phagocytosis stimulating peptide” tuftsin, H‐Thr‐Lys‐Pro‐Arg‐OH and the N‐glycosylated undecapeptide H‐Thr‐Lys‐Pro‐Arg‐Glu‐Gln‐Gln‐Tyr‐Asn(β‐ d ‐GlcNAc)‐Ser‐Thr‐OH, which correspond to the “tuftsin‐region” at the Fc‐domain of immunoglobulin G (amino acid residues 289–299), were evaluated in comparison with tuftsin and rigin, H‐Gly‐Gln‐Pro‐Arg‐OH, for their capacity to evoke the release of interleukin‐1 and tumor necrosis factor from mouse peritoneal macrophages and from human monocytes. Several glycosylated tuftsin derivatives were found to modulate, in a rather dose‐dependent manner, the release of the two cytokines from both cell types.