Portal de Periódicos da CAPES

Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

2010; Thieme Medical Publishers (Germany); Volume: 103; Issue: 03 Linguagem: Inglês

10.1160/th09-10-0716

2567-689X

Thomas J. Povsic, Mauricio G. Cohen, Christopher Rusconi, Bruce A. Sullenger, Richard Becker,

Extracellular vesicles in disease

Summary Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.