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Epidemiology of multiple sclerosis in London and Middlesex County, Ontario, Canada

1988; Lippincott Williams & Wilkins; Volume: 38; Issue: 4 Linguagem: Inglês

10.1212/wnl.38.4.617

1526-632X

Walter Hader, Margaret Elliot, George C. Ebers,

Powdery Mildew Fungal Diseases

A case-controlled epidemiologic study of multiple sclerosis (MS) was carried out in London, Ontario, and its surrounding Middlesex County for the period 1974–1983. The prevalence rates for clinically definite/probable MS on January 1, 1984 were 94/100,000 for the city and 91/100,000 for the county. The estimated annual incidence rate for the decade 1974–83 was 3.4/100,000. The female-to-male sex ratio was 2.5:1. A familial history of MS was recorded in 14.4% of close relatives and a total of 17% when distant relatives are included. The MS group is predominantly of British (70%) and European (23%) origin. The urban-rural residence pattern analysis indicates no significant regional influence on the risk of developing MS.