Post-Prostatic Massage Examination for Prediction of Asymptomatic Prostatitis in Needle Biopsies: A Prospective Study
2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 2 Linguagem: Inglês
10.1016/j.juro.2009.04.009
ISSN1527-3792
AutoresAli Tekin, Alpaslan Yüksel, Soner Tekin, Gülistan Gümrükçü, Ahmet Aslan, Feridun Şengör,
Tópico(s)Urologic and reproductive health conditions
ResumoNo AccessJournal of UrologyAdult Urology1 Aug 2009Post-Prostatic Massage Examination for Prediction of Asymptomatic Prostatitis in Needle Biopsies: A Prospective Studyis accompanied byProstate Specific Antigen, Pelvic Pain and Prostatitis—Time For a New Paradigm? Ali Tekin, Alpaslan Yuksel, Soner Tekin, Gulistan Gumrukcu, Ahmet Ruknettin Aslan, and Feridun Sengor Ali TekinAli Tekin Department of Urology, Duzce University School of Medicine, Duzce, Turkey More articles by this author , Alpaslan YukselAlpaslan Yuksel Urology Service, Ministry of Health, Siirt State Hospital, Siirt, Turkey More articles by this author , Soner TekinSoner Tekin 1st Urology Clinic, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author , Gulistan GumrukcuGulistan Gumrukcu Department of Pathology, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author , Ahmet Ruknettin AslanAhmet Ruknettin Aslan 1st Urology Clinic, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author , and Feridun SengorFeridun Sengor 1st Urology Clinic, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.04.009AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Although asymptomatic prostatitis is the most common noncancer diagnosis as demonstrated histologically by biopsies, screening and identification before biopsy remain unclear. In this study we prospectively evaluate the efficacy of examination of post-prostatic massage urine for prediction of asymptomatic prostatitis in biopsies. Materials and Methods: A total of 161 consecutive men 50 to 80 years old with serum prostate specific antigen 4.1 to 10.0 ng/ml, normal digital rectal examination, no evidence of clinical prostatitis or urinary tract infection, who underwent 8 or 10-core prostate biopsies under transrectal ultrasonography guidance were included in the study. Immediate pre-biopsy leukocyte count in post-prostatic massage urine was determined per high power field (400 ×). We selected 5, 7 and 10 leukocytes per high power field as cutoffs, and urine was examined for prediction of histological prostatitis. Results: Histological diagnosis was prostatitis, benign prostatic hyperplasia and prostate cancer in 66 (41.0%), 63 (39.1%) and 32 (19.9%) patients, respectively. The mean number of leukocytes and percentage of positive post-prostatic massage urine microscopy for all cutoffs were significantly higher in subjects with prostatitis than in those without prostatitis (p <0.0001). Histological prostatitis was predicted most accurately by the 5 leukocyte cutoff (sensitivity 68.2%, specificity 82.1% and area under the receiver operating characteristics curve 0.75). Conclusions: In asymptomatic men with mild increases of prostate specific antigen histological evidence of prostatic inflammation is common. The leukocyte count in post-prostatic massage urine appears to be useful for screening of this condition before biopsy. Our data suggest that 10 leukocytes per high power field in post-prostatic massage urine, the usually applied cutoff, may be too high for the definition of prostatic inflammation. References 1 : Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med1987; 317: 909. 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Volume 182Issue 2August 2009Page: 564-569 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsmassageprostate-specific antigenbiopsyinflammationprostatitisMetricsAuthor Information Ali Tekin Department of Urology, Duzce University School of Medicine, Duzce, Turkey More articles by this author Alpaslan Yuksel Urology Service, Ministry of Health, Siirt State Hospital, Siirt, Turkey More articles by this author Soner Tekin 1st Urology Clinic, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author Gulistan Gumrukcu Department of Pathology, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author Ahmet Ruknettin Aslan 1st Urology Clinic, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author Feridun Sengor 1st Urology Clinic, Ministry of Health, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey More articles by this author Expand All Advertisement PDF downloadLoading ...
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