Gut microbiome development along the colorectal adenoma–carcinoma sequence
2015; Nature Portfolio; Volume: 6; Issue: 1 Linguagem: Inglês
10.1038/ncomms7528
ISSN2041-1723
AutoresQiang Feng, Suisha Liang, Huijue Jia, Andreas Stadlmayr, Longqing Tang, Zhou Lan, Dongya Zhang, Huihua Xia, Xiaoying Xu, Zhuye Jie, Lili Su, Xiaoping Li, Xin Li, Junhua Li, Liang Xiao, Ursula Huber-Schönauer, David Niederseer, Xun Xu, Jumana Y. Al‐Aama, Huanming Yang, Jian Wang, Karsten Kristiansen, Manimozhiyan Arumugam, Herbert Tilg, Christian Datz, Jun Wang,
Tópico(s)Metabolomics and Mass Spectrometry Studies
ResumoColorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma. The gut microbiota is involved in the development of colorectal cancer. Here, the authors analyse the faecal microbiomes of healthy subjects and of patients with colorectal cancer or benign adenoma, revealing microbial genes, strains and functions enriched in each group.
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