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The Effect of Free Fatty Acids on Growth Hormone(GH)-Releasing Hormone-Mediated GH Secretion in Man*

1985; Oxford University Press; Volume: 60; Issue: 2 Linguagem: Inglês

10.1210/jcem-60-2-290

1945-7197

Toshihiro Imaki, Tamotsu Shibasaki, KAZUO SHIZUME, Akitsugu Masuda, Mari Hotta, Yoshino Kiyosawa, K Jibiki, Hiroshi Demura, Toshio Tsushima, Nicholas Ling,

Cancer, Hypoxia, and Metabolism

The effect of FFA on GH-releasing hormone(GHRH)-mediated secretion of GH was examined in six normalyoung men. Three of the men were infused with 250 ml of alipid-heparin solution at 1.67 ml/min for 150 min, and the otherthree were given an equivalent volume of saline in the samemanner. Thirty minutes after the start of infusion, 100 μg GHRH (the 44-amino acid form) were injected iv, and plasmaGH and FFA were measured. One week later, the same menparticipated in an identical experiment, but the ones who hadreceived lipid-heparin previously were given saline and vice versa. In both experiments, plasma FFA increased to 2.25 ± 0.16meq/liter (mean ± SEM) 60 min after the start of lipid-heparininfusion, whereas FFA levels did not change significantly in thesaline-treated group. Mean plasma GH levels reached peakconcentrations in both groups 30 min after GHRH treatment.However, the peak GH response when lipid-heparin was givenwas significantly diminished (8.4 ± 1.7 ng/ml), compared withthe peak response when saline was given (28.9 ± 7.1 ng/ml).These data suggest that plasma FFA elevations induced by lipidheparininfusion inhibit GH secretion induced by GHRH.