Metachromatic Leukodystrophy: Diagnosis with Samples of Venous Blood
1968; American Association for the Advancement of Science; Volume: 161; Issue: 3841 Linguagem: Inglês
10.1126/science.161.3841.594
ISSN1095-9203
AutoresAlan K. Percy, Roscoe O. Brady,
Tópico(s)RNA regulation and disease
ResumoArylsulfatase A and B have been demonstrated in preparations of human leukocytes. The level of activity of arylsulfatase A is markedly decreased in the preparations from patients with metachromatic leukodystrophy. Acid phosphatase and arylsulfatase B activities were normal. The assay of arylsulfatase A in leukocyte preparations can be useful in the diagnosis of metachromatic leukodystrophy while obviating the difficulties of current methods.
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