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Increased levels of soluble serum interleukin-2 receptor in extrinsic allergic alveolitis correlate with interleukin-2 receptor expression on alveolar macrophages

1994; Elsevier BV; Volume: 94; Issue: 6 Linguagem: Inglês

10.1016/0091-6749(94)90124-4

1097-6825

A Pforte, Angela Brunnera, P. Gais, M Ströbel, Georg Burger, G. Breyer, K Häußinger, Löms Ziegler-Heitbrock,

IL-33, ST2, and ILC Pathways

In a group of 20 patients with extrinsic allergic alveolitis (10 with farmer's lung, 9 with bird-breeder's lung, and 1 with humidifier's lung), we observed increased levels of soluble serum interleukin-2 receptor (ssIL-2R) with an average of 75.2 pmol (control group average, 40.6 pmol). Analysis of bronchoalveolar lavage cells by immunocytochemistry with a CD25 antibody revealed only a slight increase to 4.2% IL-2R + cells among alveolar lymphocytes but a pronounced rise to 21.2% IL-2R + cells among alveolar macrophages. Furthermore, cytometry revealed a fourfold higher IL-2R expression on a per cell basis for alveolar macrophages as compared with alveolar lymphocytes. A clear-cut positive correlation (p = 0.006) was found for ssIL-2R and IL-2R + alveolar macrophages, but only a borderline correlation was found for ssIL-2R and IL-2R + alveolar lymphocytes (p = 0.04). The finding of a concomitant decrease of IL-2R + alveolar macrophages and of ssIL-2R on allergen avoidance further supports the notion that alveolar macrophages may be the main source of the increased ssIL-2R in patients with extrinsic allergic alveolitis. (J ALLERGY CLIN IMMUNOL 1994;94:1057-64.)