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Comparative Mapping of the Actin-Binding Protein 280 Genes in Human and Mouse

1994; Elsevier BV; Volume: 21; Issue: 2 Linguagem: Inglês

10.1006/geno.1994.1288

1089-8646

Manuela Gariboldi, Elena Maestrini, Federico Canzian, Giacomo Manenti, Laura De Gregorio, Stefano Rivella, Aurobindo Chatterjee, Gail E. Herman, Nicoletta Archidiacono, Rachele Antonacci, Marco A. Pierotti, Tommaso A. Dragani, Daniela Toniolo,

Genomics and Chromatin Dynamics

Two genes encode actin-binding protein 280 isoforms. ABP-280 or filamin (FLN1) is present in the cytoskeleton of many cell types, whereas expression of FLN2 is limited to skeletal muscle and heart. FLN1 maps to human chromosome Xq28, and, by physical mapping in YAC clones, we have mapped the homologous murine locus (Fln1) to mouse chromosome X, in a region of syntenic homology with human chromosome X. We mapped FLN2 to human chromosome 7q32-q35 by analysis of somatic cell hybrids containing portions of chromosome 7, and, by using a mapping panel from an interspecific murine cross, we mapped the corresponding murine locus (Fln2) to murine chromosome 6 in a region homologous to human chromosome 7.