Combined Cardio-Renal Failure: a Key Factor in Heart Failure Progression and Therapy
2006; Elsevier BV; Volume: 59; Issue: 2 Linguagem: Inglês
10.1016/s1885-5857(06)60114-x
ISSN1885-5857
Autores Tópico(s)Blood Pressure and Hypertension Studies
ResumoCardiovascular disease is the primary cause of morbidity/mortality in the Spanish setting, justifying the extraordinary research effort being made to determine its etiopathogenesis, to predict its prognosis, and to improve treatment. In recent years there has been growing recognition of the role of kidney failure in the overall prognosis of cardiovascular disease.1 Varying in severity, kidney failure very commonly accompanies heart failure, and recent work suggest it may predict the risk of death in congestive heart disease better than either the ejection fraction or the New York Heart Association (NYHA) classification.2 In this issue of the REVISTA ESPANOLA DE CARDIOLOGIA, Grigorian-Shamagian et al3 analyze the role of kidney failure as a predictor of heart failure mortality. Their data, although collected only in hospitalized patients, bring to light information of interest to this important topic. To begin with, this is the first Spanish study on this issue that analyzes a large number of patients (n=522). Secondly, unlike other studies in which only systolic dysfunction is taken into account, the present work examines patients with both preserved and reduced systolic function. From a clinical standpoint, the results provide useful information highlighting the importance of kidney dysfunction in the progress of heart failure. How does kidney failure worsen the prognosis of heart failure? Among the patients examined by GrigorianShamagian et al, those with severe kidney failure—a problem seen among members of the subgroups with preserved and (especially) reduced systolic function—had a poorer prognosis. It should be noted that until now there have been no studies that describe possible differences in kidney function in subgroups of this type. Large scale Combined Cardio-Renal Failure: a Key Factor in Heart Failure Progression and Therapy Carlos Carameloa and Paloma Gilb
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