A New Bioactive Norquinone-Methide Triterpene from Maytenus scutioides
1998; Thieme Medical Publishers (Germany); Volume: 64; Issue: 08 Linguagem: Inglês
10.1055/s-2006-957581
ISSN1439-0221
AutoresAntonio González, Nelson Alvarenga, Isabel L. Bazzocchi, A. G. RAVELO, Laila Moujir,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoBy antimicrobial and cytotoxic-guided fractionation, a bioactive norquinone-methide triterpene, 15α-hydroxypristimerin, was isolated from a South American medicinal plant, Maytenus scutioides. Its structure was determined on the basis of spectroscopic evidence. Successful chemical transformation of pristimerin to netzahualcoyene indicates that the 15-hydroxy compounds seems to be a possible precursor of 14(15)-ene-quinone-methide-triterpenoids in the biogenetic pathway.
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