Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland
1995; Elsevier BV; Volume: 185; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(94)11213-3
ISSN1872-7972
AutoresMaarit Lehtovirta, Seppo Helisalmi, Arto Mannermaa, Hilkka Soininen, Keijo Koivisto, Markku Ryynänen, Paavo Riekkinen,
Tópico(s)Nutritional Studies and Diet
ResumoApolipoprotein E is a polymorphic protein defined by three alleles, ε2, ε3 and ε4. An increased frequency of the ε4 allele is associated with late-onset familial and sporadic Alzheimer's disease (AD). We studied 202 Finnish AD patients and 55 age- and sex-matched controls. AD patients were divided into four subgroups; sporadic early-onset, sporadic late-onset, familial early-onset and familial late-onset disease. We found no significant differences in the ε4 allele frequency between the subgroups. However, all the subgroups differed in the frequency of ε4 allele detection from the controls (P < 0.0001). In the late-onset patients, the age at onset decreased from 76 to 69 as the number of ε4 alleles increased from 0 to 2.
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