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Long‐term potentiation in the avian hippocampus does not require activation of the N‐methyl‐D‐aspartate (NMDA) receptor

1993; Wiley; Volume: 13; Issue: 2 Linguagem: Inglês

10.1002/syn.890130208

1098-2396

Andrzej Wieraszko, Gregory F. Ball,

Memory and Neural Mechanisms

Abstract Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 × 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This increase in the magnitude of the potential was not blocked by antagonists of the NMDA receptor (APV and MK‐801). These data suggest that the synaptic facilitation observed in the pigeon hippocampus, which appears to be a form of long‐term potentiation, does not depend on the activation of NMDA receptors. © 1993 Wiley‐Liss, Inc.