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Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis

2008; Elsevier BV; Volume: 16; Issue: 18 Linguagem: Inglês

10.1016/j.bmc.2008.08.033

1464-3391

Su-Kyung Lee, Hye-Nan Kim, Yeong‐Rim Kang, Chang Woo Lee, Hwan‐Mook Kim, Dong Cho Han, Jongheon Shin, KiHwan Bae, Byoung‐Mog Kwon,

Oxidative Organic Chemistry Reactions

Neolignans such as obovatol, honokiol, and magnolol have been previously reported to show various biological activities including anti-inflammation and antitumor effects. This is the first demonstration on the in vivo antitumor effect of obovatol on human colorectal carcinoma SW620 cells. Nude mice were implanted with SW620 cells and fed with vehicle or 5 mg/kg/d dose of obovatol for 20 days. Obovatol inhibited tumor growth that accounted for 50% decrease in tumor volume and 44.6% decrease in tumor weight at the end of the experiment without any adverse health effect. In nude mice bearing SW620-incubated tumor, obovatol exhibited more potent antitumor activity than honolkiol. In addition, DNA flow cytometric analysis shows that obovatol progresses to apoptosis as detected by flow cytometry after double staining with annexin V and propidium iodide. Thus, we suggest that obovatol is a potent inducer of cell apoptosis in SW620 cells, and a potent antitumor agent.