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Menopausal Flushes: a Neuroendocrine Link with Pulsatile Luteinizing Hormone Secretion

1979; American Association for the Advancement of Science; Volume: 205; Issue: 4408 Linguagem: Inglês

10.1126/science.462193

1095-9203

Robert F. Casper, S. S. C. YEN, Mahlon M. Wilkes,

Regulation of Appetite and Obesity

Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.