Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Production and characterization of Clostridium perfringens recombinant β toxoid

2012; Elsevier BV; Volume: 18; Issue: 3 Linguagem: Inglês

10.1016/j.anaerobe.2012.01.004

1095-8274

Adalgisa Milach, João Rodrigo Gil de los Santos, Carlos Gil Turnes, Ângela Nunes Moreira, Ronnie Antunes de Assis, Felipe Masiero Salvarani, Francisco Carlos Faria Lobato, Fabrício Rochedo Conceição,

Botulinum Toxin and Related Neurological Disorders

In this work, we produced and evaluated a vaccine based on a β toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT). The non-toxic rBT was innocuous for mice and induced 14 IU mL−1 of β antitoxin in rabbits, complying with the European Pharmacopeia and CFR9 - USDA guidelines.