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A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline

1973; Elsevier BV; Volume: 328; Issue: 2 Linguagem: Inglês

10.1016/0005-2795(73)90291-2

1878-1454

Richard A. Berg, Yasuo Kishida, Yuji Kobayashi, Katsuhiko Inouye, Alan E. Tonelli, Shumpei Sakakibara, Darwin J. Prockop,

Biopolymer Synthesis and Applications

A model for the triple-helical conformation of (Pro-Hyp-Gly)10 has been developed which can account for the recent observation that hydroxyproline contributes to the stability of the triple helix in aqueous solution. Previous structures proposed for (Pro-Gly-Pro)n and collagen were modified to allow the formation of a new inter-chain hydrogen bond between the hydroxyl group of hydroxyproline and the carbonyl group of glycine in an adjacent chain. To create this hydrogen bond, the new model postulates a cis peptide bond between glycine and proline.