Portal de Periódicos da CAPES

Psoriasis vulgaris coexistent with epidermolysis bullosa acquisita

1997; Oxford University Press; Volume: 137; Issue: 5 Linguagem: Inglês

10.1046/j.1365-2133.1997.19532043.x

1365-2133

Yukie Endo, A. Tamura, Osamu Ishikawa, Yoshiki Miyachi, Takashi Hashimoto,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Autoimmune bullous diseases, such as bullous pemphigoid or pemphigus vulgaris, occasionally develop in psoriatic patients. In addition, a novel subepidermal bullous disease with autoantibodies against a lower lamina lucida antigen of 200 kDa has recently been reported in association with psoriasis. We describe here a patient with psoriasis vulgaris who developed epidermolysis bullosa acquisita (EBA). Direct immunofluorescence revealed linear deposition of IgG and C3 at the basement membrane zone. The patient's serum bound to the dermal side of salt-split normal human skin. However, immunoblot analysis demonstrated that the patient's serum reacted with an EBA antigen of 290 kDa. EBA should be included in the list of autoimmune diseases associated with psoriasis vulgaris.