Portal de Periódicos da CAPES

Inclusion Complexation of Novocaine by β-Cyclodextrin in Aqueous Solutions

2006; American Chemical Society; Volume: 71; Issue: 12 Linguagem: Inglês

10.1021/jo052666n

1520-6904

Emilia Iglesias,

Analytical Methods in Pharmaceuticals

The formation of inclusion complexes between β-cyclodextrin (β-CD) and the local anesthetic 2-(diethylamino)ethyl-p-amino-benzoate (novocaine) in aqueous solutions under different acidity conditions, using steady-state fluorescence or UV−vis spectroscopies, electrical conductivity, or the kinetic study of both the nitrosation reaction of the primary amine group in a mild acid medium and the hydrolysis of the ester function under an alkaline medium, has been studied. The inclusion complex formation between neutral or protonated novocaine and β-CD of 1:1 stoichiometry was observed; however, the magnitude of the binding constants depends on the nature of both the guest and the host, and the higher-affinity guest−host was found under conditions when both the novocaine and the β-CD were neutral molecules.