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Development of the Paris Definition of Early Crohn's Disease for Disease-Modification Trials: Results of an International Expert Opinion Process

2012; Lippincott Williams & Wilkins; Volume: 107; Issue: 12 Linguagem: Inglês

10.1038/ajg.2012.117

1572-0241

Laurent Peyrin‐Biroulet, Vincent Billioud, Geert R. DʼHaens, Remo Panaccione, Brian G. Feagan, Julián Panés, Silvio Danese, Stefan Schreiber, Haruhiko Ogata, Toshifumi Hibi∥, Peter Higgins, Laurent Beaugerie, Yehuda Chowers, Édouard Louis, Flávio Steinwurz, Walter Reinisch, Paul Rutgeerts, Jean‐Frédéric Colombel, Simon Travis, William J. Sandborn,

Helicobacter pylori-related gastroenterology studies

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.