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Jerk-locked back averaging and dipole source localization of magnetoencephalographic transients in a patient with epilepsia partialis continua

1997; Elsevier BV; Volume: 103; Issue: 4 Linguagem: Inglês

10.1016/s0013-4694(97)00040-0

1872-6380

Hiroshi Shigeto, Shozo Tobimatsu, Takato Morioka, Tomoya Yamamoto, Takuro Kobayashi, Motohiro Kato,

Glycogen Storage Diseases and Myoclonus

In order to localize the generator site of epileptiform discharges, we applied the techniques of jerk-locked back averaging (JBA) of magnetoencephalographic (MEG) activities and dipole source localization in a patient with epilepsia partialis continua (EPC), who showed continuous, focal myoclonic jerks in the right arm. The myoclonic discharges in the right muscle were used as a trigger pulse. JBA revealed consistent EEG and MEG transients that coincided consistently and constantly preceded the myoclonic jerks. The estimated dipoles of MEG were localized in a restricted area in the left precentral area, which closely correlated with the area of epileptic discharges recorded in electrocorticography. Therefore, JBA of MEG is considered to be a useful non-invasive method for localizing the epileptogenic area in EPC.