Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells
2012; Cell Press; Volume: 37; Issue: 6 Linguagem: Inglês
10.1016/j.immuni.2012.08.026
ISSN1097-4180
AutoresEhud Zigmond, Chen Varol, Júlia Farache, Elinor Elmaliah, Ansuman T. Satpathy, Gilgi Friedlander, Matthias Mack, Nahum Y. Shpigel, Ivo G. Boneca, Kenneth M. Murphy, Guy Shakhar, Zamir Halpern, Steffen Jung,
Tópico(s)Immune cells in cancer
ResumoLy6Chi monocytes seed the healthy intestinal lamina propria to give rise to resident CX3CR1+ macrophages that contribute to the maintenance of gut homeostasis. Here we report on two alternative monocyte fates in the inflamed colon. We showed that CCR2 expression is essential to the recruitment of Ly6Chi monocytes to the inflamed gut to become the dominant mononuclear cell type in the lamina propria during settings of acute colitis. In the inflammatory microenvironment, monocytes upregulated TLR2 and NOD2, rendering them responsive to bacterial products to become proinflammatory effector cells. Ablation of Ly6Chi monocytes ameliorated acute gut inflammation. With time, monocytes differentiated into migratory antigen-presenting cells capable of priming naive T cells, thus acquiring hallmarks reminiscent of dendritic cells. Collectively, our results highlight cellular dynamics in the inflamed colon and the plasticity of Ly6Chi monocytes, marking them as potential targets for inflammatory bowel disease (IBD) therapy.
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