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Molecular domains of myelinated axons

2000; Elsevier BV; Volume: 10; Issue: 5 Linguagem: Inglês

10.1016/s0959-4388(00)00122-7

1873-6882

Elior Peles, James L. Salzer,

S100 Proteins and Annexins

Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na+ channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K+ channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junctions in the organization of these domains have emerged.