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BIBTEX RIS

Malondialdeído e grupo sulfidrila como biomarcadores do estresse oxidativo em pacientes com lúpus eritematoso sistêmico

2012; Elsevier BV; Volume: 52; Issue: 4 Linguagem: Inglês

10.1590/s0482-50042012000400016

ISSN

1809-4570

Autores

Yenly G. Pérez, Lissett Caridad González Pérez, Rita de Cássia Mascarenhas Netto, Domingos Sávio Nunes de Lima, Émerson Silva Lima,

Tópico(s)

Systemic Lupus Erythematosus Research

Resumo

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin associated with oxidative stress. The present study aimed to investigate the presence of oxidative stress in patients with newly diagnosed SLE. SLE patients (n = 36) and control subjects (n = 28) were enrolled in this study. Blood samples were used for malondialdehyde (MDA), sulfhydryl groups (SH) and uric acid determination. MDA levels (µmol/L) were higher in patients (3.9 ± 2.6) than in control subjects (1.6 ± 2.6). SH were significantly lower in SLE patients. The findings suggest that MDA can be a good marker of oxidative stress in SLE.

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