An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR
2007; Elsevier BV; Volume: 253; Issue: 2 Linguagem: Inglês
10.1016/j.canlet.2007.01.026
ISSN1872-7980
AutoresGuiqin Hou, Lexun Xue, Zhaoming Lu, Tianli Fan, Fang Tian, Yanli Xue,
Tópico(s)Cancer-related gene regulation
ResumomTOR/p70S6K pathway is considered a central regulator in various malignant tumors, but its roles in esophageal squamous cell carcinoma (ESCC), which is a common cause of mortality in China, remain unknown. Here, we identify that the mTOR/p70S6K pathway is activated in ESCC; rapamycin and siRNA against mTOR rapidly inhibited expression of mTOR and the phosphorylation of its major downstream effectors, p70S6K and 4E-BP1, arrested cells in the G0/G1 phase and induced apoptosis of ESCC cells. The findings may lay a foundation for making further investigations on the mTOR/p70S6K pathway as a potential target for ESCC therapy.
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