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Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells

2009; Elsevier BV; Volume: 17; Issue: 5 Linguagem: Inglês

10.1016/j.bmc.2009.01.037

1464-3391

Liang‐Wen Zheng, Lingling Wu, Bao‐Xiang Zhao, Wen‐Liang Dong, Jun‐Ying Miao,

Bioactive Compounds and Antitumor Agents

A series of novel 3-aryl-1-(4-tert-butylbenzyl)-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound (E)-1-(4-tert-butylbenzyl)-N′-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide (3e) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer cells.