Cyclopolyamines: Synthesis of cyclospermidines and cyclospermines, analogues of spermidine and spermine
1994; Elsevier BV; Volume: 35; Issue: 46 Linguagem: Inglês
10.1016/s0040-4039(00)78449-8
ISSN1873-3581
AutoresGuy Brand, Mir Wais Hosseini, Romain Ruppert,
Tópico(s)Synthesis and Biological Evaluation
ResumoThe synthesis of a series of cyclic analogues of the naturally occurring polyamines putrescine, spermidine and spermine was achieved. The cyclic analogues of putrescine named cycloputrescine [4,n] were composed of cycloputrescine in which the two primary amines were connected with a polymethylene chain of variable length (n = 3, 4, 5). Cyclospermidines [4,n] and Cyclospermines [4,n] were composed of a cycloputrescine [4,n] moiety mono- or di-functionalized with an aminopropyl chain respectively.
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