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Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination.

1993; BMJ; Volume: 307; Issue: 6907 Linguagem: Inglês

10.1136/bmj.307.6907.769

0959-8138

Anthony Peter Passmore, K Wilson-Davies, Cora Stoker, Marjorie Scott,

Gastrointestinal motility and disorders

To compare the efficacy and cost effectiveness of a senna-fibre combination and lactulose in treating constipation in long stay elderly patients.Randomised, double blind, cross over study.Four hospitals in Northern Ireland, one hospital in England, and two nursing homes in England.77 elderly patients with a history of chronic constipation in long term hospital or nursing home care.A senna-fibre combination (10 ml daily) or lactulose (15 ml twice daily) with matching placebo for two 14 day periods, with 3-5 days before and between treatments.Stool frequency, stool consistency, and ease of evacuation; deviation from recommended dose; daily dose and cost per stool; adverse effects.Mean daily bowel frequency was greater with the senna-fibre combination (0.8, 95% confidence interval 0.7 to 0.9) than lactulose (0.6, 0.5 to 0.7; t = 3.51 p < or = 0.001). Scores for stool consistency and ease of evacuation were significantly higher for the senna-fibre combination than for lactulose. The recommended dose was exceeded more frequently with lactulose than the senna-fibre combination (chi 2 = 8.38, p or = 0.01). As an index of the standard daily dose, the dose per stool was 1.52 for lactulose and 0.97 for the senna-fibre combination, at a cost per stool of 39.7p for lactulose and 10.3p for senna-fibre. Adverse effects were no different for the two treatments.Both treatments were effective and well tolerated for chronic constipation in long stay elderly patients. The senna-fibre combination was significantly more effective than lactulose at a lower cost.