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The NADH Electrochemical Detection Performed at Carbon Nanofibers Modified Glassy Carbon Electrode

2007; Wiley; Volume: 19; Issue: 14 Linguagem: Inglês

10.1002/elan.200703879

1521-4109

Adina Arvinte, Federica Valentini, Antonio Radoi, Fabiana Arduini, Emanuela Tamburri, Lucian Rotariu, Giuseppe Palleschi, Camelia Bala,

Advanced biosensing and bioanalysis techniques

Abstract In this work, the capability of carbon nanofibers to be used for the design of catalytic electrochemical biosensors is demonstrated. The direct electrochemistry of NADH was studied at a glassy carbon electrode modified using carbon nanofibers. A decrease of the oxidation potential of NADH by more than 300 mV is observed in the case of the assembled carbon nanofiber‐glassy carbon electrode comparing with a bare glassy carbon electrode. The carbon nanofiber‐modified electrode exhibited a wide linear response range of 3×10 −5 to 2.1×10 −3 mol L −1 with a correlation coefficient of 0.997 for the detection of NADH, a high specific sensitivity of 3637.65 (μA/M cm 2 ), a low detection of limit (LOD=3 σ ) of 11 μM, and a fast response time (3 s). These results have confirmed the fact that the carbon nanofibers represent a promising material to assemble electrochemical sensors and biosensors.