V H 4—21, A Human V H Gene Segment Overrepresented in the Autoimmune Repertoire
1992; Wiley; Volume: 35; Issue: 1 Linguagem: Inglês
10.1002/art.1780350103
ISSN1529-0131
Autores Tópico(s)Lymphoma Diagnosis and Treatment
ResumoArthritis & RheumatismVolume 35, Issue 1 p. 11-18 ArticleFree to Read VH4—21, A Human VH Gene Segment Overrepresented in the Autoimmune Repertoire Virginia Pascual MD, Virginia Pascual MD Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.Search for more papers by this authorJ. Donald Capra MD, Corresponding Author J. Donald Capra MD Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9048Search for more papers by this author Virginia Pascual MD, Virginia Pascual MD Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.Search for more papers by this authorJ. Donald Capra MD, Corresponding Author J. Donald Capra MD Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9048Search for more papers by this author First published: January 1992 https://doi.org/10.1002/art.1780350103Citations: 94AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Kirsch IR, Morton CC, Nakahara K, Leder P: Human immunoglobulin heavy chain genes mapped to a region of translocation in malignant B lymphocytes. Science 216: 301–303, 1982 2 Cox DW, Markovic VD, Teshima IE: Genes for immunoglobulin heavy chains and for alpha1-antitrypsin are localized to specific regions of chromosome 14q. Nature 297: 428–430, 1982 3 Tonegawa S: Somatic generation of antibody diversity. Nature 302: 575–581, 1983 4 Pascual V, Capra JD: Human immunoglobulin heavy-chain variable region genes: organization, polymorphism end expression. Adv Immunol 49: 1–73, 1991 5 Rechavi G, Ram D, Glazer L, Zakut R, Givol D: Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups. Proc Natl Acad Sci USA 80: 855–859, 1983 6 Lee KH, Matsuda F, Kinashi T, Kodaira M, Honjo T: A novel family of variable region genes of the human immunoglobulin heavy chain. J Mol Biol 195: 761–768, 1987 7 Humphries CG, Shen A, Kuziel WA, Capra JD, Blattner FR, Tucker PW: A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumors. Nature 331: 446–449, 1988 8 Buluwela L, Rabbitts TH: A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes. Eur J Immunol 18: 1843–1845, 1988 9 Berman JE, Mellis SJ, Pollock R, Smith CL, Suh H, Heinke B, Kowal C, Surti U, Chess L, Cantor CR, Alt FW: Content and organization of the human Ig VH locus: definition of three new families and linkage to the Ig CH locus. EMBO J 7: 727–738, 1988 10 Schroeder HW, Walter MA, Hofker MH, Ebens A, van Dijk KW, Liao LC, Cox DW, Milner ECB, Perlmutter RM: Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements. Proc Natl Acad Sci USA 85: 8196–8200, 1988 11 Bofill M, Janossey G, Janossa M, Burford GD, Seymore GJ, Wernet P, Kelemen E: Human B cell development. II. Subpopulations in the human fetus. J Immunol 134: 1531–1538, 1985 12 Gathings WE, Lawton AR, Cooper MD: Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin diversity in humans. Eur J Immunol 7: 804–810, 1977 13 Yancopoulos GD, Desiderio SV, Paskin M, Kearney JF, Baltimore D, Alt FW: Preferential utilization of the most JH proximal VH segments in pre–B cell lines. Nature 311: 727–733, 1984 14 Perlmutter RM, Kearney JF, Chang SP, Hood LH: Developmentally controlled expression of immunoglobulin VH genes. Science 227: 1597–1601, 1985 15 Holtmberg D, Forsgren S, Ivars F, Coutinho A: Reactions among IgM antibodies derived from normal neonatal mice. Eur J Immunol 14: 435–441, 1984 16 Kearney JF, Vakil M, Nicholson N: Non-random VH gene expression in early B cells, Evolution and Vertebrate Immunity: The Antigen Receptor and MHC Gene Families. Edited by G Kelso, D Shulze. Austin, University of Texas Press, 1987 17 Arant SE, Griffin JA, Koopman WJ: VH gene expression is restricted in anti-IgG antibodies from MLR autoimmune mice. J Exp Med 164: 1284–1300, 1986 18 Shlomchick MS, Nemazee DA, Sato VL, van Snick J, Carson DA, Weigert MG: Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors): a structural explanation for the high frequency of IgM anti-IgG cells. J Exp Med 164: 407–427, 1986 19 Kofler RF, Dixon J, Theophilopoulos AN: The genetic origin of autoantibodies. Immunol Today 8: 374–380, 1987 20 Painter CJ, Monestier M, Chew A, Bona-Dimitriu A, Kasturi K, Bailey C, Scott VE, Sidman CL, Bona CA: Specificities and V genes encoding autoantibodies from viable motheaten mice. J Exp Med 167: 1137–1153, 1988 21 Klinman NR, Linton PJ: The clonotype repertoire of B-cell subpopulations. Adv Immunol 42: 1–93, 1988 22 Gu H, Tarlinton D, Muller W, Rajewsky K, Forster I: Most peripheral B cells in mice are ligand selected. J Exp Med 173: 1357–1371, 1991 23 Schroeder HW, Hillson JL, Perlmutter RM: Early restriction in the human antibody repertoire. Science 238: 791–793, 1987 24 Schroeder HW, Wang JW: Preferential utilization of conserved immunoglobulin heavy chain variable region gene segments during human fetal life. Proc Natl Acad Sci USA 87: 6146–6150, 1990 25 Logtemberg T, Schutte M, Inghirami G, Berman JE, Gmelig-Meyling HJ, Insel RA, Knowles DM, Alt FW: Immunoglobulin VH gene expression in human B-cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemias. Int Immunol 1: 362–366, 1990 26 Sanz I, Casali P, Thomas JW, Notkins AL, Capra JD: Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. J Immunol 142: 4054–4061, 1989 27 Dersimonian H, Schwartz RS, Barrett KJ, Stollar BD: Relationship of human variable region heavy chain germ line gene to genes encoding anti-DNA autoantibodies. J Immunol 139: 2496–2501, 1987 28 Robbins DL, Kenny TP, Coloma MJ, Gavilondo-Cowley JV, Soto-Gil RW, Chen PP, Larrick JW: Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells. Arthritis Rheum 33: 1188–1195, 1990 29 Siminovitch KA, Misener V, Kwong PC, Song QL, Chen PP: A natural autoantibody is encoded by germ line heavy and lambda light chain variable region genes without somatic mutation. J Clin Invest 84: 1675–1678, 1989 30 Pascual V, Randen I, Thompson K, Sioud M, Forre O, Natvig JB, Capra JD: The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from EBV transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis: further evidence that some autoantibodies are unmutated copies of germ line genes. J Clin Invest 86: 1320–1328, 1990 31 Silberstein LE, Litwin S, Carmack CE: Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-PR2 erythrocyte autoantibodies. J Exp Med 169: 1631–1643, 1989 32 Sanz I, Dang H, Takei M, Talal N, Capra JD: VH sequence of a human anti-Sm autoantibody: evidence that autoantibodies can be unmutated copies of germ line genes. J Immunol 142: 883–887, 1989 33 Spatz LA, Wong KK, Williams M, Desai R, Golier J, Berman JE, Alt FW, Latov N: Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. J Immunol 144: 2821–2828, 1990 34 Cairns EP, Kwong C, Misener V, Ip P, Bell DA, Siminovitch KA: Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. J Immunol 143: 685–691, 1989 35 Hoch S, Schwaber J: Identification and sequence of the VH gene elements encoding a human anti-DNA antibody. J Immunol 139: 1689–1693, 1987 36 Davidson A, Manheimer-Lory A, Aranow C, Peterson R, Hannigan N, Diamond B: Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes. J Clin Invest 85: 1401–1409, 1990 37 Pascual V, Victor K, Lelsz D, Spellerberg MB, Hamblin TJ, Thompson KM, Randen I, Natvig JB, Capra JD, Stevenson FK: Nucleotide sequence analysis of the V regions of two IgM cold agglutinins: evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J Immunol 146: 4385–4391, 1991 38 Roudier J, Silverman GJ, Chen PP, Carson DA, Kipps TJ: Intraclonal diversity in the VH genes expressed by CD5 chronic lymphocytic leukemia producing pathologic IgM rheumatoid factor. J Immunol 144: 1526–1530, 1990 39 Van Es JH, Gmelig-Meyling FHJ, van de Akker WRM, Aanstoot H, Derksen RHWM, Logtemberg T: Somatic mutations in the variable regions of a human IgG anti-double stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J Exp Med 173: 461–470, 1991 40 Van der Heijden RWJ, Bunschoten H, Pascual V, Uytdehaag FGCM, Osterhaus ADME, Capra JD: Nucleotide sequence of a human monoclonal anti-idiotypic antibody specific for a rabies virus-neutralizing monoclonal antibody reveals extensive somatic variability suggestive of an antigen driven immune response. J Immunol 144: 2835–2839, 1990 41 Logtemberg T, Young FM, Van Es JH, Gmelig-Meyling FHJ, Alt FW: Autoantibodies encoded by the most JH-proximal human immunoglobulin heavy chain variable region gene. J Exp Med 170: 1347–1355, 1989 42 Baer R, Chen K, Smith SD, Rabbitts TH: Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors. Cell 43: 705–713, 1985 43 Stevenson FK, Smith GJ, North J, Hamblin TJ, Glennie MJ: Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity. Br J Haematol 72: 9–15, 1989 44 Sanz I, Kelly P, Williams C, Scholl S, Tucker P, Capra JD: The smaller VH gene families display remarkably little polymorphism. EMBO J 8: 3741–3748, 1989 45 Stevenson FK, Wrightham M, Glennie MJ, Jones DB, Cattan AR, Feizi T, Hamblin TJ, Stevenson GT: Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors. Blood 68: 430–436, 1986 46 Levy S, Campbell MJ, Levy R: Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline Vk genes to downstream Jk segments in a murine cell line. J Exp Med 170: 1–13, 1989 47 Timmers E, Kenter M, Thompson A, Kraakman ME, Bergman JE, Alt FW, Schuurman RKB: Diversity of immunoglobulin heavy chain gene segment rearrangements in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients. Eur J Immunol (in press) 48 Thompson KM, Sutherland J, Barden G, Melamed MD, Randen I, Pascual V, Capra JD, Natvig JB, Stevenson FK: Preferential utilization of the VH4–21 variable region gene segment by human IgM but not IgG monoclonal antibodies against blood group antigens. Scand J Immunol (in press) 49 Andris SJ, Johnson S, Zolla-Pazner S, Capra JD: Molecular characterization of five human anti-HIV-1 antibody heavy chains reveals extensive somatic mutation typical of an antigen driven immune response. Proc Natl Acad Sci 88: 7783–7787, 1991 50 Dighiero G, Lymbery P, Guilbert B, Ternynck T, Avrameas S: Natural autoantibodies constitute a substantial part of normal circulating immunoglobulins. Ann N Y Acad Sci 135: 135–145, 1986 51 Casali P, Notkins AL: Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ lymphocytes. Annu Rev Immunol 7: 513–535, 1989 52 Dellabona P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D: Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 62: 1115–1121, 1990 53 Hillson JL, Perlmutter RM: Autoantibodies and the fetal antibody repertoire. Int Immunol 5: 215–229, 1990 54 Sasso EH, Silverman GE, Mannik M: Human IgM molecules that bind to Staphylococcal protein A contain VHIII heavy chains. J Immunol 142: 2778–2783, 1989 55 Sato T, Matsuda F, Lee KH, Shin EK, Honjo T: Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus. Biochem Biophys Res Commun 154: 265–271, 1988 56 Baer R, Foster A, Rabbitts TH: The mechanism of chromosome 14 inversion in a human T cell lymphoma. Cell 50: 97–105, 1988 57 Erikson J, Radic MZ, Camper SA, Hardy RR, Carmack C, Weigert M: Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349: 331–334, 1991 Citing Literature Volume35, Issue1January 1992Pages 11-18 ReferencesRelatedInformation
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