Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium
1996; Wiley; Volume: 39; Issue: 1 Linguagem: Inglês
10.1002/art.1780390103
ISSN1529-0131
AutoresH. Michael Belmont, Steven B. Abramson, J. T. Lie,
Tópico(s)Complement system in diseases
ResumoArthritis & RheumatismVolume 39, Issue 1 p. 9-22 ReviewFull Access Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium H. Michael Belmont MD, Corresponding Author H. Michael Belmont MD Hospital for Joint Diseases and the New York University Medical Center, New York, New YorkHospital for Joint Diseases, 301 East 17th Street, New York, NY 10003Search for more papers by this authorSteven B. Abramson MD, Steven B. Abramson MD Hospital for Joint Diseases and the New York University Medical Center, New York, New YorkSearch for more papers by this authorJ. T. Lie MD, J. T. Lie MD University of California Davis School of Medicine, DavisSearch for more papers by this author H. Michael Belmont MD, Corresponding Author H. Michael Belmont MD Hospital for Joint Diseases and the New York University Medical Center, New York, New YorkHospital for Joint Diseases, 301 East 17th Street, New York, NY 10003Search for more papers by this authorSteven B. Abramson MD, Steven B. Abramson MD Hospital for Joint Diseases and the New York University Medical Center, New York, New YorkSearch for more papers by this authorJ. T. Lie MD, J. T. Lie MD University of California Davis School of Medicine, DavisSearch for more papers by this author First published: January 1996 https://doi.org/10.1002/art.1780390103Citations: 197AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Gharavi AE, Chu JL, Elkon KB: Autoantibodies to intracellular proteins in human systemic lupus erythematosus are not due to random polyclonal B cell activation. Arthritis Rheum 31: 1337–1345, 1988 2 Gleichmann E, van Elven EH, van der Veen JPW: A systemic lupus erythematosus (SLE)-like disease in mice induced by T-B cell cooperation: preferential formation of autoantibodies characteristic of SLE. Eur J Immunol 12: 152–159, 1982 3 Budman DR, Merchant EB, Steinberg AD, Doft B, Gershwin ME, Lizzio E, Reeves JP: Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE. Eur J Immunol 15: 1154–1156, 1985 4 Theofilopoulos AN, Dixon FJ: Etiopathogenesis of murine systemic lupus erythematosus. Immunol Rev 55: 179–216, 1981 5 Abdou NI, Sagawa A, Pascual E, Herbert J, Sadeghee S: Suppressor T cell abnormality in idiopathic systemic lupus erythematosus. Clin Immunol Immunopathol 6: 192–199, 1976 6 Bresnihan B, Jasin HE: Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest 59: 106–116, 1977 7 Fauci AS, Steinberg AD, Haynes BF, Whalen G: Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol 121: 1473–1978, 1978 8 Walport M, Ng YC, Lachmann PJ: Erythrocytes transfused into patients with SLE and hemolytic anaemia lose complement receptor type 1 from their cell surface. Clin Exp Immunol 69: 501–507, 1987 9 Frank MM, Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH: Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 300: 518–523, 1979 10 Salmon JE, Kimberly RP, Gibofsky A, Fotino M: Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization. J Immunol 133: 2525–2431, 1984 11 Liszewski MK, Kahl LE, Atkinson JP: The functional role of complement genes in systemic lupus erythematosus and Sjögrens syndrome. Curr Opin Rheumatol 1: 347–352, 1989 12 Lie JT: Vasculopathy in the antiphospholipid syndrome: thrombosis or vasculitis, or both? J Rheumatol 16: 713–715, 1989 13 Lie JT: Vasculitis in the antiphospholipid syndrome: culprit or consort? J Rheumatol 21: 397–399, 1994 14 Lie JT, Kobayashi S, Tokano Y, Hashimoto H: Systemic and cerebral necrotizing vasculitis coexisting with disseminated coagulopathy in systemic lupus erythematosus associated with antiphospholipid syndrome. J Rheumatol (in press) 15 Baehr G, Klemperer P, Schifrin A: A diffuse disease of the peripheral circulation (usually associated with lupus erythematosus and endocarditis). Trans Assoc Am Physicians 50: 139–155, 1935 16 Klemperer P, Pollack AD, Baehr G: Pathology of disseminated lupus erythematosus. Arch Pathol 32: 569–631, 1941 17 Baldwin DS, Gluck MC, Lowenstein J, Gallo GR: Lupus nephritis: clinical course as related to morphological forms and their transition. Am J Med 62: 12–30, 1977 18 Bhathena DB, Sobel BJ, Migdal SD: Noninflammatory renal microangiopathy of systemic lupus erythematosus (lupus vasculitis). Am J Nephrol 1: 144–159, 1981 19 Bhuyan UN, Malaviya AN, Dash SC, Malhotra KK: Prognostic significance of renal angiitis in systemic lupus erythematosus (SLE). Clin Nephrol 20: 109–113, 1983 20 Tsumagari T, Fukumato S, Kinjo M, Tanaka K: Incidence and significance of intrarenal vasculopathies in patients with systemic lupus erythematosus. Hum Pathol 16: 43–49, 1985 21 Grishman E, Venkatasehan VS: Vascular lesions in lupus nephritis. Mod Pathol 1: 235–241, 1988 22 Doherty NE, Siegel RJ: Cardiovascular manifestations of systemic lupus erythematosus. Am Heart J 110: 1257–1265, 1985 23 Mandell BF: Cardiovascular involvement in systemic lupus erythematosus. Semin Arthritis Rheum 17: 126–141, 1987 24 Sturfelt G, Eskilsson J, Nived O, Truedsson L, Valina S: Cardiovascular disease in systemic lupus erythematosus. Medicine (Baltimore) 71: 216–223, 1992 25 Schwab EP, Schumacher HR, Freundlich B, Calligari PE: Pulmonary alveolar hemorrhage in systemic lupus erythematosus. Semin Arthritis Rheum 23: 8–15, 1993 26 Lie JT: Rheumatic connective tissue disease. In, Pulmonary Pathology. Second edition. Edited by DH Dail, SP Hammar. New York, Springer-Verlag, 1994 27 Kistin MG, Kaplan MM, Harrington JT: Diffuse ischemic colitis associated with systemic lupus erythematosus: response to subtotal colectomy. Gastroenterology 75: 1147–1151, 1978 28 Zizic TM, Classen JN, Stevens MB: Acute abdominal complications of systemic lupus erythematosus and polyarteritis nodosa. Am J Med 73: 525–531, 1982 29 Helliwell TR, Flook D, Whitworth J, Day DW: Arteritis and venulitis in systemic lupus erythematosus resulting in massive lower intestinal hemorrhage. Histopathology 9: 1103–1113, 1985 30 Laing TJ: Gastrointestinal vasculitis and pneumatosis intestinalis due to systemic lupus erythematosus: successful treatment with pulse intravenous cyclophosphamide. Am J Med 85: 555–558, 1988 31 Winkelmann RK, Schroeder AL, Kierland RR, Ryan TM: Clinical studies of lividoid vasculitis (segmental hyalinizing vasculitis). Mayo Clin Proc 49: 746–750, 1974 32 Gilliam JN, Smiley JD: Cutaneous necrotizing vasculitis and related disorders. Ann Allergy 37: 328–339, 1976 33 Marin OSM, Estanol BV: Cerebral vasculitis presenting as a meningoencephalitis: a case of systemic lupus erythematosus. Delaware Med J 45: 315–319, 1973 34 Ellis SG, Verity MA: Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955–1977. Semin Arthritis Rheum 8: 212–221, 1979 35 Abramowsky CR, Vegas ME, Swinehart G, Gyves MT: Decidual vasculopathy of placenta in lupus erythematosus. N Engl J Med 303: 668–672, 1980 36 Suzuki Y, Kitagawa Y, Matsuoka Y, Fukuda J, Mizushima Y: Severe cerebral and systemic necrotizing vasculitis developing during pregnancy in a case of systemic lupus erythematosus. J Rheumatol 17: 1408–1411, 1990 37 Lie JT: Takayasu's arteritis. In, Systemic Vasculitides. Edited by A Churg, J Churg. New York, Igaku-Shoin, 1991 38 Igarashi T, Nagaoka S, Matsunaga K, Katoh K, Ishigatsiho Y, Tani K, Lie JT: Aortitis syndrome (Takayasu's arteritis) associated with systemic lupus erythematosus. J Rheumatol 16: 1579–1583, 1989 39 Saxe PA, Altman RD, Igarashi T, Tani K, Lie JT: Aortitis syndrome (Takayasu's arteritis) associated with SLE. J Rheumatol 17: 1251–1252, 1990 40 Saxe PA, Altman RD: Takayasu's arteritis syndrome associated with systemic lupus erythematosus. Semin Arthritis Rheum 21: 295–305, 1992 41 Lorber M, Gershwin ME, Shoenfeld Y: The coexistence of systemic lupus erythematosus with other autoimmune diseases: the kaleidoscope of autoimmunity. Semin Arthritis Rheum 24: 105–113, 1994 42 Mintz G, Galindo L, Fernandez-Diez J, Jimenez FJ, Robles-Saavedra E, Enriquez-Casillas R: Acute massive pulmonary hemorrhage in systemic lupus erythematosus. J Rheumatol 5: 39–50, 1978 43 Eagen JW, Memoli V, Roberts J, Matthew GR, Schwartz MM, Lewis EJ: Pulmonary hemorrhage in systemic lupus erythematosus. Medicine (Baltimore) 57: 545–560, 1978 44 Leatherman JW, Davies S, Hoidal J: Alveolar hemorrhage syndrome: diffuse microvascular lung hemorrhage in immune and idiopathic disorders. Medicine (Baltimore) 63: 343–361, 1984 45 Abud-Mendoza C, Diaz-Jananen E, Alarcón-Segovia D: Fatal pulmonary hemorrhage in systemic lupus erythematosus. J Rheumatol 2: 558–561, 1985 46 Onomura K, Nakata H, Tanaka Y, Tsuda T: Pulmonary hemorrhage in patients with systemic lupus erythematosus. J Thorac Imag 6: 57–61, 1991 47 Rodriguez-Iturbe B, Garcia R, Rubio L, Cuenca L: Immunohistologic findings in the lung in systemic lupus erythematosus. Arch Pathol Lab Med 101: 342–344, 1977 48 Eagen JW, Roberts J, Schwartz M, Lewis EJ: The composition of pulmonary immune deposits in systemic lupus erythematosus. Clin Immunol Immunopathol 12: 204–219, 1978 49 Myers JL, Katzenstein AL: Microangiitis in lupus induced pulmonary hemorrhage. Am J Clin Pathol 85: 552–556, 1986 50 Pines A, Kaplinsky N, Olchovsky D, Rozenman J, Frankl O: Pleuropulmonary manifestations of systemic lupus erythematosus: clinical features of its subgroups, prognostic and therapeutic implications. Chest 88: 129–135, 1985 51 Miller LR, Greenberg S, McLarty J: Lupus lung. Chest 88: 265–269, 1985 52 Segal AM, Calabrese L, Ahmad M, Tubbs R, White CS: The pulmonary manifestations of systemic lupus erythematosus. Semin Arthritis Rheum 14: 202–224, 1985 53 Erickson RW, Franklin WA, Emlen W: Treatment of hemorrhagic lupus pneumonitis with plasmapheresis. Semin Arthritis Rheum 24: 114–123, 1994 54 Hill GS: Systemic lupus erythematosus and mixed connective tissue disease. In, Pathology of the Kidney. Fourth edition. Edited by RH Heptinstall. Boston, Little, Brown and Company, 1992 55 Katz SM, Kern S, Umlas SL, DeHoratius RJ: Renal vascular lesions in systemic lupus erythematosus. Ann Clin Lab Sci 20: 147–153, 1990 56 Nesher G, Hanna VE, Moore TL, Hersh M, Osborn TG: Thrombic microangiopathic hemolytic anemia in systemic lupus erythematosus. Semin Arthritis Rheum 24: 165–172, 1994 57 Jain R, Chartash E, Susin M, Furie R: Systemic lupus erythematosus complicated by thrombotic microangiopathy. Semin Arthritis Rheum 24: 173–182, 1994 58 Koeffler P, Schur P, Kunkel H: Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126: 607–624, 1967 59 Fauci TY, Haynes BF, Katz P: The spectrum of vasculitis. Ann Intern Med 89: 660–676, 1978 60 Arthus M: Injections repetees de serum de cheval chez la lapin. Soc Biol 1903 61 Ishizaka K: Gamma globulin and molecular mechanisms in hypersensitivity reactions. Prog Allergy 7: 32–40, 1963 62 Frank MM, Ellman L, Green I, Cochrane C: Site of deposition of C3 in Arthus reactions of C4 deficient guinea pigs. J Immunol 110: 1447–1451, 1973 63 Lawley TJ, Frank MM: Immune complexes and immune complex diseases. In, Clinical Immunology. Edited by CW Parker. Philadelphia, WB Saunders, 1980 64 Cochrane CG: The Arthus reaction. In, The Inflammatory Process. Edited by BW Zweifach, L Grant, RT McCluskey. New York, Academic Press, 1965 65 Sylvestre DL, Ravetch JV: Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science 265: 1095–1098, 1994 66 Dixon FJ, Feldman JD, Vazquez JJ: Experimental glomerulonephritis: the pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113: 899–920, 1961 67 Cochrane CG, Koffler D: Immune complex disease in experimental animals and man. In, Advances in Immunology. Edited by FJ Dixon, HG Kunkel. New York, Academic Press, 1973 68 Belmont HM, Hopkins P, Edelson HS, Kaplan HB, Ludewig R, Weissmann G, Abramson S: Complement activation during systemic lupus erythematosus: C3a and C5a anaphylatoxins circulate during exacerbations of disease. Arthritis Rheum 29: 1085–1089, 1986 69 Hopkins P, Belmont M, Buyon J, Philips MR, Weissmann G, Abramson SB: Increased plasma anaphylotoxins in systemic lupus erythematosus predict flares of the disease and may elicit the adult cerebral distress syndrome. Arthritis Rheum 31: 632–641, 1988 70 Belmont HM, Buyon J, Giorno R, Abramson S: Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus: the Shwartzman phenomenon revisited. Arthritis Rheum 37: 376–383, 1994 71 Jacob HS, Craddock PR, Hammerschmidt DE, Moldow CF: Complement-induced granulocyte aggregation: an unsuspected mechanism of disease. N Engl J Med 302: 789–794, 1980 72 Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS: Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Lancet 1: 947–949, 1980 73 Hakim R, Breillatt J, Lazarus M, Prt K: Complement activation and hypersensitivity reactions to hemodialysis membranes. N Engl J Med 311: 878–882, 1984 74 Craddock P, Fehr J, Dalmasso A, Brigham K, Jacob H: Hemodialysis leukopenia. J Clin Invest 59: 879–888, 1977 75 Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Balckstone EH, Kirklin SW: Complement activation during cardiopulmonary bypass. N Engl J Med 304: 497–505, 1981 76 Perez HD, Horn JK, Ong R, Goldstein I: Complement (C5)-derived chemotactic activity in serum from patients with pancreatitis. J Lab Clin Med 101: 123–129, 1983 77 Shwartzman G: Phenomenon of Local Tissue Reactivity. New York, Paul Hoeber, 1937 78 Argenbright L, Barton R: Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo: the Shwartzman phenomenon revisited. J Clin Invest 89: 259–273, 1992 79 Abramson SB, Weissmann G: Complement split products and the pathogenesis of SLE. Hosp Prac 23: 45–55, 1988 80 Pohlman TM, Stanness KA, Beatty PG, Ochs HD, Harlan JM: An endothelial cell surface factor induced in vitro by lipopolysaccharide, interleukin-1, and tumor necrosis factor increased neutrophil adherence by a CDw18 dependent mechanism. J Immunol 136: 4548–4553, 1986 81 Pober JS, Gimbrone M, Lapierre D, Mendrick L, Fiers W, Rothlein R, Springer T: Overlapping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor and immune interferon. J Immunol 137: 1893–1896, 1986 82 Fletcher MP, Seligmann BE, Gallin JI: Correlation of human neutrophil secretion, chemoattractant receptor mobilization and enhanced functional capacity. J Immunol 128: 941–948, 1982 83 Buyon J, Tamerius J, Belmont HM, Abramson S: Assessment of disease activity and impending flare in patients with systemic lupus erythematosus: comparison of the use of complement split products and conventional measurements of complement. Arthritis Rheum 35: 1028–1037, 1992 84 Schur PH, Sandson J: Immunologic factors and clinical activity in systemic lupus erythematosus. N Engl J Med 278: 533–538, 1968 85 Buyon JP, Shadick N, Berkman R, Hopkins P, Dalton J, Weissmann G, Winchester R, Abramson SB: Surface expression of gp 165/95, the complement receptor CR3, as a marker of disease activity in systemic lupus erythematosus. Clin Immunol Immunopathol 46: 141–149, 1988 86 Philips MR, Abramson SB, Weissmann G: Neutrophil adhesion and autoimmune vascular injury. Clin Aspects Autoimmun 3: 3–15, 1989 87 Johnson RT, Richardson EP: The neurological manifestations of systemic lupus erythematosus: a clinical pathological study of 24 cases and a review of the literature. Medicine (Baltimore) 47: 337–369, 1968 88 Hanley JG, Walsh NMG, Sangalang V: Brain pathology in systemic lupus erythematosus. J Rheumatol 19: 732–741, 1992 89 Hammad A, Tsukada Y, Torre N: Cerebral occlusive vasculopathy in systemic lupus erythematosus and speculation on the part played by complement. Ann Rheum Dis 51: 550–552, 1992 90 Devinsky O, Petito CK, Alonso DR: Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis heart emboli and thrombotic thrombocytopenic purpura. Ann Neurol 23: 380–384, 1988 91 Abramson SB, Dobro J, Eberle MA, Benton M, Reibman J, Epstein H, Belmont HM, Rapoport DM, Goldring RM: The syndrome of acute reversible hypoxemia of systemic lupus erythematosus. Ann Intern Med 114: 941–947, 1991 92 Bone RC: Why new definitions of sepsis and organ failure are needed. Am J Med 95: 348–350, 1993 93 Nogare D: Septic shock. Am J Med Sci 302: 50–65, 1991 94 Waage A, Brandtzaeg P, Espevik T, Halstensen A: Current understanding of the pathogenesis of gram-negative shock. Infect Dis Clin North Am 5: 781–789, 1991 95 Walsh CJ, Carey PD, Bechard DE, Fowler AA, Sugerman HJ: Anti-CD 18 antibody attenuates neutropenia and alveolar capillary-membrane injury during gram-negative sepsis. Surgery 110: 205–211, 1991 96 Macworth-Young CG, Loizou S, Walport MJ: Antiphospholipid antibodies and disease. Q J Med 72: 767–777, 1989 97 McNeil HP, Chesterman CN, Krilis SA: Immunology and clinical importance of antiphospholipid antibodies. Adv Immunol 49: 193–280, 1991 98 Hughes GRV: The antiphospholipid syndrome: ten years on. Lancet 342: 341–344, 1993 99 Tanaka M, Kobayashi S, Tamura N, Hashimoto H, Hirose SI: Disseminated intravascular coagulation in a patient with systemic lupus erythematosus with lupus anticoagulant. Intern Med 32: 513–517, 1993 100 Cervera R, Asherson RA, Lie JT: Clinicopathologic correlations in antiphospholipid syndromes. Semin Arthritis Rheum 24: 262–272, 1995 101 Lie JT: Pathology of antiphospholipid syndromes. In, The Antiphospholipid Syndrome. Edited by RA Asherson, R Cervera, JC Piette, Y Schoenfeld. Boca Raton, FL, CRC Press (in press) 102 Zelger B, Sepp N, Schmid KW, Hintner H, Klein G, Fritsch PO: Life history of cutaneous vascular lesions in Sneddon's syndrome. Hum Pathol 23: 668–567, 1992 103 Hughson MD, McCarty GA, Sholer CM, Brumback RA: Thrombotic cerebral arteriopathy in patients with the antiphospholipid syndrome. Mod Pathol 6: 644–653, 1993 104 D'Cruz D, Hughes G: Antibodies, thrombosis and the endothelium. Br J Rheumatol 33: 2–4, 1994 105 Yoshio T, Masuyama JI, Sumiya M, Minota S, Kano S: Antiendothelial cell antibodies and their relation to pulmonary hypertension in systemic lupus erythematosus. J Rheumatol 21: 2058–2063, 1994 106 Harris EN, Gharavi AE, Hughes GRV: Antiphospholipid antibodies. Clin Rheum Dis 11: 591–609, 1985 107 Harris EN, Chan JKH, Asherson RA, Aber VR, Gharavi AE, Hughes GRV: Thrombosis, recurrent fetal loss and thrombocytopenia: predictive value of the anticardiolipin antibody test. Arch Intern Med 146: 2153–2156, 1986 108 Asherson RA: The catastrophic antiphospholipid syndrome. J Rheumatol 19: 508–512, 1992 109 Pérez RE, McClendon JR, Lie JT: Primary antiphospholipid syndrome with multiorgan arterial and venous thrombosis. J Rheumatol 19: 1289–1292, 1992 110 Mackworth-Young CG, David J, Louizou S, Walport MJ: "Primary" antiphospholipid syndrome: features of patients with raised anticardiolipin antibodies and no other disorders. Ann Rheum 48: 362–367, 1989 111 Asherson RA, Khamashta MA, Ordi-Ros J, Derken RHW, Machin SJ, Barquinero J, Outt HH, Harris EN, Vilardell-Thorres M, Hughes GRV: The "primary" antiphospholipid syndrome: major clinical and serologic features. Medicine (Baltimore) 68: 366–374, 1989 112 Vianna JL, Khamashta MA, Ordi-Rios J, Font J, Cervera R, Lopez-Soto A, Tolosa C, Fraz J, Selva A, Ingelmo M, Vilardell M, Hughes GRV: Comparison of the primary and secondary antiphospholipid syndrome: a European multicenter study of 114 patients. Am J Med 96: 3–9, 1994 113 Kant KS, Pollak VE, Weiss MA, Glueck HI, Miller MA, Hess EV: Glomerular thrombosis in systemic lupus erythematosus: prevalence and significance. Medicine (Baltimore) 60: 71–87, 1981 114 Hughson MD, Nadasdy T, McCarty GA, Sholer C, Min KW, Silva F: Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Kidney Dis 20: 150–158, 1992 115 Harris EN, Gharavi AE, Asherson RA, Boey MA, Hughes GRV: Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol 2: 47–51, 1984 116 Derkson RHWM, Bouma BN, Kater L: The association between the lupus anticoagulant and cerebral infarction in systemic lupus erythematosus. Scand J Rheumatol 15: 179–184, 1986 117 The Antiphospholipid Antibodies in Stroke Study Group: Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. Stroke 21: 1268–1273, 1990 118 Asherson RA, Ridley M, Fletcher CDM, Hughes GRV: Systemic lupus erythematosus, pulmonary hypertension and adult respiratory distress syndrome. Clin Exp Rheumatol 6: 301–304, 1988 119 Andonopoulos AP: Adult respiratory distress syndrome: an unrecognized postmortem event in systemic lupus erythematosus. Br J Rheumatol 30: 346–348, 1991 120 Hillerdal G, Hagg A, Licke G, Wegenius G, Scheibenpflug L: Intraalveolar haemorrhage in the anticardiolipin antibody syndrome. Scand J Rheumatol 20: 58–62, 1991 121 Gertner E, Lie JT: Pulmonary capillaritis, alveolar hemorrhage, and recurrent microvascular thrombosis in primary antiphospholipid syndrome. J Rheumatol 20: 1224–1228, 1993 122 Alegre VA, Gastineau DA, Winkelmann RK: Skin lesions associated with circulating lupus anticoagulant. Br J Dermatol 120: 419–429, 1989 123 Grob JJ, Bonerandi JJ: Thrombotic skin disease as a marker of the anticardiolipin syndrome: livido vasculitis and distal gangrene associated with abnormal serum antiphospholipid activity. J Am Acad Dermatol 20: 1063–1069, 1989 124 McCalmont CS, McCalmont TH, Jorizzo JL, White WL, Leshin B, Rothberger H: Livido vasculitis: vasculitis or thrombotic vasculopathy? Clin Exp Dermatol 17: 4–8, 1992 125 Gertner E, Lie JT: Systemic therapy with fibrinolytic therapy and heparin for recalcitrant nonhealing cutaneous ulcer in the antiphospholipid syndrome. J Rheumatol 21: 2159–2161, 1994 126 Hughes GR, Khamashta MA: The antiphospholipid syndrome. J R Coll Physicians Lond 28: 301–304, 1994 127 Ordi-Ros J, Perez-Peman P, Monasterio J: Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). Haemostasis 24: 165–174, 1994 128 Bevers EM, Galli M: Cofactors involved in the antiphospholipid syndrome. Lupus 1: 51–53, 1992 129 Ozawa N, Makino T, Matsubayashi H, Hosokawa, Someya K, Nozawa S, Matsuura E: Beta 2-GPI-dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions. J Clin Lab Anal 8: 255–259, 1994 130 Aron AL, Gharavi AE, Shoenfeld Y: Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome. Int Arch Allergy Immunol 106: 8–12, 1995 131 Pierangeli SS, Harris EN: Antiphospholipid antibodies in an in vivo thrombosis model in mice. Lupus 3: 247–251, 1994 132 Triplett DA: Antiphospholipid antibodies: proposed mechanisms of action. Am J Reprod Immunol 28: 211–215, 1992 133 Wiener HM, Vardinon N, Yust I: Platelet antibody binding and spontaneous aggregation in 21 lupus anticoagulant patients. Vox Sanguinis 61: 111–121, 1991 134 Vazquez-Mellado J, Llorente L, Richaud-Patin Y, Alarcón-Segovia D: Exposure of anionic phospholipids upon platelet activation permits binding of beta 2 glycoprotein I and through it that of IgG antiphospholipid antibodies: studies in platelets from patients with antiphospholipid syndrome and normal subjects. J Autoimmun 7: 335–348, 1994 135 Lindsey NJ, Hendeson FI, Malia R, Milford-Ward MA, Greaves M, Hughes P: Inhibition of prostacyclin release by endothelial binding anticardiolipin antibodies in thrombosisprone patients with systemic lupus erythematosus and the antiphospholipid syndrome. Br J Rheumatol 33: 20–26, 1994 136 Westerman EM, Miles JM, Backonja M, Sundstrom WR: Neuropathologic findings in multi-infarct dementia associated with anticardiolipin antibody: evidence for endothelial injury as the primary event. Arthritis Rheum 35: 1038–1041, 1992 137 McCraw KR, DeMichele A, Samuels P, Roth D, Kuo A, Meng QH, Rauch J, Cines DB: Detection of endothelial cell-reactive immunoglobulin in patients with anti-phospholipid antibodies. Br J Haematol 79: 595–605, 1991 138 Silver RK, Adler L, Hickman AR, Hageman JR: Anticardiolipin antibody-positive serum enhances endothelial cell plateletactivating factor production. Am J Obset Gynecol 165: 1748–1752, 1991 139 Freyssinet JM, Toti-Orfanoudakis F, Ravanat C, Grunebaum L, Gauchy J, Cazenave JP, Wiesel ML: The catalytic role of anionic phospholipids in the activation of protein C by factor Xa and expression of its anticoagulant function in human plasma. Blood Coagul Fibrinolysis 2: 691–698, 1991 140 Joseph J, Scopelitis E: Seronegative antiphospholipid syndrome associated with plasminogen activator inhibitor. Lupus 3: 201–203, 1994 141 Ahmed K, Vianna J, Khamashta M, Hughes G: IL-2, IL-6, and TNF levels in primary antiphospholipid antibody syndrome (letter). Clin Exp Rheumatol 10: 503, 1992 142 Stricker RB, Davis JA, Gershow J, Yamamoto KS, Kiprov DD: Thrombotic thrombocytopenic purpura complicating systemic lupus erythematosus: case report and literature review from the plasmapheresis era. J Rheumatol 19: 1469–1473, 1992 143 Cockerell CJ, Lewis JE: Systemic lupus erythematosus-like illness associated with syndrome of abnormally large von Willebrand's factor multimers. South Med J 86: 951–953, 1993 144 Moake JL, Rudy CK, Troll JH, Weinstein MJ, Colannino NM, Azocar J, Seder RH, Hong SL, Deykin D: Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med 303: 1432–1435, 1982 145 Takahashi H, Hanano M, Wada K, Tatewaki W, Niwano H, Tsubouchi J, Nakano M, Nakamura T, Shibata A: Circulating thrombomodulin in thrombotic thrombocytopenic purpura. Am J Hematol 38: 174–177, 1991 146 Belmont HM, Levartovsky D, Amin AR, Skovron ML, Buyon J, Giorno R, Rediske J, Abramson SB: Upregulated expression of inducible nitric oxide synthase in SLE: evidence for activated endothelium (abstract). Arthritis Rheum 38 (Suppl 9): S390, 1995 147 Paulson JC: Selectin/carbohydrate-mediated adhesion of leukocytes. In, Adhesion: Its Role in Inflammatory Disease. Edited by JM Harlan, DY Liu. New York, WH Freeman, 1992 Citing Literature Volume39, Issue1January 1996Pages 9-22 ReferencesRelatedInformation
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