Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury
2012; American Association for the Advancement of Science; Volume: 338; Issue: 6103 Linguagem: Inglês
10.1126/science.1223821
ISSN1095-9203
AutoresHiroyuki Miyoshi, Rieko Ajima, Christine T. Luo, Terry P. Yamaguchi, Thaddeus S. Stappenbeck,
Tópico(s)Epigenetics and DNA Methylation
ResumoGut, Heal Thyself Foods, drugs, and pathogens all represent possible threats to our guts on a daily basis. Fortunately, the gut is quite good at repairing itself—but how? Working in mice, Miyoshi et al. (p. 108 , published online 6 September; see the Perspective by Barrett ) selectively injured intestinal crypts containing intestinal stem cells and observed therepair process. The noncanonical Wnt ligand, Wnt5a, was required for crypt regeneration. Wnt5a inhibited intestinal stem cell proliferation, which paradoxically promoted regeneration of crypt tissue.
Referência(s)