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Short-Term Endocrinological Results after Gamma Knife Surgery of Pituitary Adenomas

1998; Karger Publishers; Volume: 70; Issue: Suppl. 1 Linguagem: Inglês

10.1159/000056415

1423-0372

I. Morange‐Ramos, J. Régis, Henry Dufour, J Andrieu, F. Grisoli, P. Jaquet, J.C. Peragut,

Adrenal and Paraganglionic Tumors

We report our preliminary results after the radiosurgical treatment of 25 secreting pituitary adenomas with a mean follow-up of 20 months (range 6-36 months). Fifteen acromegalic patients showed a decrease of 65% in mean growth hormone (GH) levels after 6 months and of 77% after 12 months. Only 3 patients (20%) are considered to be in remission (mean GH and IGF1 level into the normal range). A decrease of prolactin (PRL) was noted in 46% and 64% at 6 and 12 months after radiosurgery in 4 patients with prolactinomas. There was no case of PRL normalizaion. At present 3/4 patients have individual PRL levels slightly above the normal range. A normalization of Urinary Free Cortisol (UFC) was noticed in 4/6 (66%) patients Cushing's disease within 6-12 months. Pituitary deficiency was noticed in this series in 4/25 patients (16%) who received subtotal or total pituitary irradiation for large postoperative remnants of secreting adenomas poorly defined on magnetic resonance imaging (MRI).