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Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

2008; Elsevier BV; Volume: 16; Issue: 7 Linguagem: Inglês

10.1016/j.bmc.2008.02.005

1464-3391

Stanton Kok, Roberto Gambari, Chung Chui, Wing‐Yiu Yu, Eva Lin, Raymond Wong, Fung Lau, Gregory Yin Ming Cheng, Kim Hung Lam, Sau Hing Chan,

Advanced Synthetic Organic Chemistry

Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.