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Fitness of Pandemic H1N1 and Seasonal influenza A viruses during Co-infectionEvidence of competitive advantage of pandemic H1N1 influenza versus seasonal influenza

2009; Public Library of Science; Volume: 1; Linguagem: Inglês

10.1371/currents.rrn1011

2157-3999

Daniel R. Pérez, Erin M. Sorrell, Matthew Angel, Jianqiang Ye, Danielle Hickman, Lindomar Pena, Gloria Ramírez, J. Brian Kimble, Yonas Araya,

Viral gastroenteritis research and epidemiology

On June 11, 2009 the World Health Organization (WHO) declared a new H1N1 influenza pandemic. This pandemic strain is as transmissible as seasonal H1N1 and H3N2 influenza A viruses. Major concerns facing this pandemic are whether the new virus will replace, co-circulate and/or reassort with seasonal H1N1 and/or H3N2 human strains. Using the ferret model, we investigated which of these three possibilities were most likely favored. Our studies showed that the current pandemic virus is more transmissible than, and has a biological advantage over, prototypical seasonal H1 or H3 strains.