Expression of protein kinase C subspecies in rat retina
1992; Wiley; Volume: 309; Issue: 3 Linguagem: Inglês
10.1016/0014-5793(92)80818-2
ISSN1873-3468
AutoresNaoko Fujisawa, Kouji Ogita, Naoaki Saito, Yasutomi Nishizuka,
Tópico(s)Protein Kinase Regulation and GTPase Signaling
ResumoAn extract of rat retina was subjected to Mono Q followed by chromatography on hydroxyapatite, and the protein kinase C (PKC) subspecies were identified by immunobiol and biochemical analysis. It was found that, although the relative activities assayed with myelin basic protein as a common phosphate acceptor vary greatly with one another, the α‐, βI‐, βII‐, γ‐, δ‐, ε‐, ξ‐, and another structurally unknown PKC subspecies are expressed in this tissue. Thus, the retina is a unique tissue which expresses most of the PKC subspecies so far identified in mammals.
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