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Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters

1996; Elsevier BV; Volume: 37; Issue: 18 Linguagem: Inglês

10.1016/0040-4039(96)00498-4

1873-3581

David R. Barn, J. Richard Morphy, David C. Rees,

Analytical Chemistry and Chromatography

A new method for the synthesis of amino amides using Wang or Tentagel-PHB resins is described. The method uses aluminium chloride to promote the conversion of resin-bound benzylic esters to amides under ambient conditions. The reactions were monitored in 'real-time' using 13C gel phase NMR.