Fabrication and Evaluation of Chitin‐Based Nerve Guidance Conduits Used to Promote Peripheral Nerve Regeneration
2009; Wiley; Volume: 11; Issue: 11 Linguagem: Inglês
10.1002/adem.200900120
ISSN1527-2648
AutoresYumin Yang, Jian Wu, Xiao‐Dong Wang, Jie Liu, Fei Ding, Xiaosong Gu,
Tópico(s)Hydrogels: synthesis, properties, applications
ResumoChitin product was prepared from the chitosan counterpart and both were found to be equally biocompatible with cultured Schwann cells. Chitin- and chitosan-based nerve guidance conduits (NGCs) were surgically implanted to bridge 10-mm-long neural defects in rat sciatic nerves. The regenerative outcome provided positive evidence that chitin- and chitosan-based NGCs produce the similar beneficial effects on peripheral nerve regeneration.
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