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C 35 Terpenoids from the Bark of Calocedrus macrolepis var. formosana with Activity against Human Cancer Cell Lines

2006; American Chemical Society; Volume: 69; Issue: 11 Linguagem: Inglês

10.1021/np0600550

1520-6025

Chin-Lin Hsieh, Mei-Huims Tseng, Yi-Yuan Shao, Jang‐Yang Chang, Ching‐Chuan Kuo, Chi-Yen Chang, Yueh‐Hsiung Kuo,

Traditional and Medicinal Uses of Annonaceae

Ferrugicadinol (1) and ferrugieudesmol (2), two new compounds with a unique C35 terpene skeleton, were isolated from the bark of Calocedrus macrolepis var. formosana. Their structures were elucidated principally from spectroscopic evidence. The two new C35 terpenes showed cytotoxicity against human oral epidermoid carcinoma KB cells with IC50 values ranging from 11 to 14 μM.