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Trypanocidal tetrahydrofuran lignans from Peperomia blanda

2007; Elsevier BV; Volume: 69; Issue: 2 Linguagem: Inglês

10.1016/j.phytochem.2007.08.012

1873-3700

Lidiane Gaspareto Felippe, Débora Cristina Baldoqui, Massuo J. Kato, Vanderlan da Silva Bolzani, Elsie Franklin Guimarães, Regina Maria Barreto Cicarelli, Maysa Furlan,

Plant Parasitism and Resistance

Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastereomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y.